Publication

発表論文

2018

Y. Moriizumi, K.V. Tabata, R. Watanabe, T. Doura, M. Kamiya, Y. Urano and H. Noji
"Hybrid cell reactor system from Escherichia coli protoplast cells and arrayed lipid bilayer chamber device"
(2018) Sci. Rep., 8, 11757
Accepted

S. Ota†, R. Horisaki†, Y. Kawamura†, M. Ugawa†, I. Sato, K. Hashimoto, R. Kamesawa, K. Setoyama, S Yamaguchi, K. Fujiu, K. Waki, H. Noji (†equal contributions)
"Ghost cytometry"
(2018) Science 360, 1246-1251
Accepted

R. Watanabe, T. Sakuragi, H. Noji and S. Nagata
"Single-molecule analysis of phospholipid scrambling by TMEM16F"
(2018) Proc. Natl. Acad. Sci. USA 115, 3066-3071
Accepted

R. Watanabe, N. Soga, S. Ohdate and H. Noji
"Single-Molecule Analysis of Membrane Transporter Activity by Means of a Microsystem"
(2018) Bacterial Multidrug Exporters. Methods in Molecular Biology, 1700, 321-330
published online

R. Watanabe, M. Genda, Y. Kato-Yamada and H. Noji
"Essential Role of the ε Subunit for Reversible Chemo-Mechanical Coupling in F1-ATPase"
(2018) Biophys. J., 114, 178-187
published online

Y. Tamiya, R. Watanabe, H. Noji, C. Li and T. Komatsuzaki
"Effects of non-equilibrium angle fluctuation on F1-ATPase kinetics induced by temperature increase"
(2018) Phys. Chem. Chem. Phys., 20, 1872-1880
published online

2017

J. Li, G. He, H. Ueno, W. Liu, H Noji, C. Qi and X. Guo
"Direct measurement of single-molecule adenosine triphosphatase hydrolysis dynamics"
(2017) ACS Nano, 11, 12789-12795
published online

T. Muraoka, K. Umetsu, K.V. Tabata, T. Hamada, H. Noji, T. Yamashita and K. Kinbara
"Mechano-Sensitive Synthetic Ion Channels"
(2017) J. Am. Chem. Soc. 139, 18016–18023
published online

A. Nakamura, T. Tasaki, Y. Okuni, C. Song, K. Murata, T. Kozai, M. Hara, H. Sugimoto, K. Suzuki, T. Watanabe, T. Uchihashi, H. Noji and R. Iino
"Rate constants, processivity, and productive binding ratio of chitinase A revealed by single-molecule analysis"
(2017) Phys. Chem. Chem. Phys., 20, 3010-3018
published online

2016

J. Li, G. He, H. Ueno, C. Jia, H. Noji, C. Qi and X. Guo
"Direct real-time detection of single proteins using silicon nanowire-based electrical circuits"
(2016) Nanoscale, 8, 16172-16176
published online

R. Watanabe, N. Soga, M. Hara and H. Noji
"Arrayed water-in-oil droplet bilayers for membrane transport analysis"
(2016) Lab Chip, 16, 3043-304
published online

M. Baba, K. Iwamoto, R. Iino, H. Ueno, M. Hara, A. Nakanishi, J. Kishikawa, H. Noji and K. Yokoyama
"Rotation of artificial rotor axles in rotary molecular motors"
(2016) Proc. Natl. Acad. Sci. USA, 113, 11214-11219
published online

D.G.G. McMillan, R. Watanabe, H. Ueno, G.M. Cook and H. Noji
"Biophysical Characterization of a Thermoalkaliphilic Molecular Motor with a High Stepping Torque Gives Insight into Evolutionary ATP Synthase Adaptation"
(2016) J. Biol. Chem., 291, 23965-23977
published online

H. Isojima, R. Iino, Y. Niitani, H. Noji and M. Tomishige
"Direct observation of intermediate states during the stepping motion of kinesin-1"
(2016) Nat. Chem. Biol., 12,290–297
published online

Y. Matsumoto, S. Sakakihara, A. Grushnikov, K. Kikuchi, H. Noji, A. Yamaguchi, R. Iino, Y. Yagi and K. Nishino
"A Microfluidic Channel Method for Rapid Drug-Susceptibility Testing of Pseudomonas aeruginosa"
(2016) Plos One, 11,e0148797
published online

2015

C. Li, H. Ueno, R. Watanabe, H. Noji and T. Komatsuzaki
"ATP hydrolysis assists phosphate release and promotes reaction ordering in F1-ATPase"
(2015) Nat. Commun., 6, 1023
published online

R. Watanabe, N. Soga and H. Noji
"Novel Nano-Device to Measure Voltage-Driven Membrane Transporter Activity"
(2015) IEEE Transactions on Nanotechnology, 15, 70-73
published online

R. Hayashi, K. Sasaki, S. Nakamura, S. Kudo, Y. Inoue, H. Noji and K. Hayashi
"Giant Acceleration of diffusion observed in a single-molecule experiment on F1-ATPase"
(2015) Phys. Rev. Lett., 114, 248101
published online

Y. Obayashi, R. Iino and H. Noji
"A single-molecule digital enzyme assay using alkaline phosphatase with a cumarin-based fluorogenic substrate"
(2015) Analyst, 140, 5065-5073
published online

N. Soga, R. Watanabe and H. Noji
"Attolitre-sized lipid bilayer chamber array for rapid detection of single transporters"
(2015) Sci. Rep., 5, 11025
published online

H. Fujita, T. Esaki, T. Masujima, S.H. Kim, H. Noji and T. M. Watanabe
"Comprehensive chemical secretory measurement of single cell trapped in micro-droplet array with mass spectrometry"
(2015) RSC Adv., 5, 16968-16971
published online

S. Enoki, R. Iino, Y. Niitani, Y. Minagawa, M. Tomishige and H. Noji
"High-speed angle-resolved imaging of single gold nanorod with microsecond temporal resolution and one-degree angle precision"
(2015) Ana. Chem., 87, 2079-2086
published online

R. Watanabe, K. Koyasu, H. You, M. Tanigawara and H. Noji
"Torque transmission mechanism via DELSEED loop of F1-ATPase"
(2015) Biophys. J., 108, 1144-1152
published online

2014

A. Yukawa, R. Iino, R. Watanabe, S. Hayashi and H. Noji
"Key Chemical Factors of Arginine Finger Catalysis of F1-ATPase Clarified by an Unnatural Amino Acid Mutation"
(2014) Biochemistry, 54, 472-480
published online

R. Watanabe, N. Soga, T. Yamanaka and H. Noji
"High-throughput formation of lipid bilayer membrane arrays with an asymmetric lipid composition"
(2014) Sci. Rep., 4, 7076
published online

T. Muraoka, T. Endo, K.V. Tabata, H. Noji, S. Nagatoishi, K. Tsumoto, R. Li and K. Kinbara
"Reversible Ion Transportation Switch by a Ligand-Gated Synthetic Supramolecular Ion Channel"
(2014) J. Am. Chem. Soc., 136, 15584–15595
published online

M. Ui, K. Harima, T. Takei, K. Tsumoto, K.V. Tabata, H. Noji, S. Endo, K. Akiyama, T. Muraoka and K. Kinbara
"Grafting synthetic transmembrane units to the engineered low-toxicity α-hemolysin to restore its hemolytic activity"
(2014) Mol. BioSyst., 10, 3199-3206
published online

H. Ueno, Y. Minagawa, M. Hara, R. Suhaila, I. Yamato, E. Muneyuki, H. Noji, T. Murata and R. Iino
"Torque generation of Enterococcus hirae V-ATPase"
(2014) J. Biol. Chem., 289, 31212-31223
published online

R. Watanabe, Y. Minagawa and H. Noji
"Thermodynamic analysis of F1-ATPase rotary catalysis using high-speed imaging"
(2014) Protein Sci., 23, 1773-1779
published online

H. Yaginuma, S. Kawai, K.V. Tabata, K. Tomiyama, A. Kakizuka, T. Komatsuzaki, H. Noji and H. Imamura
"Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging."
(2014) Sci. Rep., 4, 6522
published online

J. Kishikawa, A. Seino, A. Nakanishi, N.E. Tirtom, H. Noji, K. Yokokawa and K. Hayashi
"F-subunit reinforces torque generation in V-ATPase"
(2014) Eur. Biophys. J., 43, 415-422
published online

R. Watanabe†, N. Soga†, D. Fujita†, K.V. Tabata, L. Yamauchi, S.H. Kim, D. Asanuma, M. Kamiya, Y. Urano, H. Suga and H. Noji (†equal contributions)
"Arrayed Lipid Bilayer Chambers Allow Single-Molecule Analysis of Membrane Transporter Activity"
(2014) Nat. Commun., 5, 4519
published online

R. Watanabe, Y. Matsukage, A. Yukawa, K.V. Tabata and H. Noji
"Robustness of the Rotary Catalysis Mechanism of F1-ATPase"
(2014) J. Biol. Chem., 289, 19331-19340
published online

T. Ikeda, T. Tsukahara, R. Iino, M. Takeuchi and H. Noji
"Motion Capture and Manipulation of Single Synthetic Molecular Rotors by Optical Microscopy"
(2014) Angew. Chem., 53, 10082-10085
published online  

T. Ikeda, R. Iino and H. Noji
"Real-Time Fluorescence Visualization of Slow Tautomerization of Single Free-Base Phthalocyanines under Ambient Conditions"
(2014) Chem. Commun., 50, 9443-9446
published online  

H.C. Arai, A. Yukawa, J.R. Iwatate, M. Kamiya, R. Watanabe, Y. Urano and H. Noji
"Torque generation mechanism of F1-ATPase upon NTP binding"
(2014) Biophys. J., 107, 156-164
published online

T. Tanaka, K. Nagashima, N. Inagaki, H. Kioka, S. Takashima, H. Fukuoka, H. Noji, A. Kakizuka and H. Imamura
"Glucose-stimulated Single Pancreatic Islets Sustain Increased Cytosolic ATP Levels during Initial Ca2+ Influx and Subsequent Ca2+ Oscillations"
(2014) J. Biol. Chem., 289, 2205-2216
published online

R. Watanabe and H. Noji
"Characterization of the temperature-sensitive reaction of F1-ATPase by using single molecule manipulation"
(2014) Sci. Rep., 4, 4962
published online

Y. Shibafuji, A. Nakamura, T. Uchihashi, N. Sugimoto, S. Fukuda, H. Watanabe, M. Samejima, T. Ando, H. Noji, A. Koivula, K. Igarashi and R. Iino
"Single-molecule imaging analysis of elementary reaction steps of Trichoderma Reesei cellobiohydrolase I (Cel7A) hydrolyzing crystalline cellulose Iα and IIII"
(2014) J. Biol. Chem., 289, 14056-14065
published online

R. Watanabe and H. Noji
"Timing of inorganic phosphate release modulates the catalytic activity of ATP-driven rotary motor protein"
(2014) Nat. Commun., 5, 3486
published online

2013

S.H. Kim, X. He, S. Kaneda, J. Kawada, D. Fourmy, H. Noji and T. Fujii
"Quantifying genetically inserted fluorescent protein in single iPS cells to monitor Nanog expression using electroactive microchamber arrays"
(2013) Lab Chip, 14, 730-736
published online

H. Kioka, H. Kato, M. Fujikawa, O. Tsukamoto, T. Suzuki, H. Imamura, A. Nakano, S. Higo, S. Yamazaki, T. Matsuzaki, K. Tkafuji, H. Asanuma, M. Asakura, T. Minamino, Y. Shintani, M. Yoshida, H. Noji, M. Kitakaze, I. Komuro, Y. Asano and S. Takashima
"Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation"
(2013) Proc. Natl. Acad. Sci. USA, 111, 273-278
published online

R. Watanabe, K. Hayashi, H. Ueno and H. Noji
"Catalysis-enhancement via rotary fluctuation of F1-ATPase"
(2013) Biophys. J., 105, 2385-2391
published online

Y. Minagawa, H. Ueno, M. Hara, Y. Ishizuka-Katsura, N. Ohsawa, T. Terada, M. Shirouzu, S. Yokoyama, I. Yamato, E. Muneyuki, H. Noji, T. Murata and R. Iino
"Basic properties of rotary dynamics of the molecular motor Enterococcus hirae V1-ATPase"
(2013) J. Biol. Chem., 288, 32700-32707
published online

D. Okuno, M. Nishiyama and H. Noji
"Single molecule analysis of the rotation of F1-ATPase under high hydrostatic pressure"
(2013) Biophys. J., 105, 1635-1642
published online

M. Toei and H. Noji
"Single-molecule analysis of FoF1-ATP synthase inhibited by N,N-dicyclohexylcarbodiimide"
(2013) J. Biol. Chem., 288, 25717-25726
published online

T. Tsuyama, J. Kishikawa, Y.W. Han, Y. Harada, A. Tsubouchi, H. Noji, A. Kakizuka, K. Yokoyama, T. Uemura and H. Imamura
"In vivo fluorescent ATP imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATPbiosensor optimized for low temperatures"
(2013) Anal. Chem., 85, 7889-7896
published online

R. Watanabe, K.V. Tabata, R. Iino, H. Ueno, M. Iwamoto, S. Oiki, H. Noji
"Biased Brownian stepping rotation of FoF1-ATP synthase driven by proton motive force"
(2013) Nat. Commun., 4, 1631
published online

2012

N.E. Tirtom, D. Okuno, M. Nakano, K. Yokoyama and H. Noji
"Mechanical Modulation of ATP-Binding Affinity of V1-ATPase"
(2012) J. Biol. Chem., 288, 619-623
published online

T. Muraoka, T. Shima, T. Hamada, M. Morita, M. Takagi, K.V. Tabata, H. Noji and K. Kinbara
"Ion Permeation by a Folded Multiblock Amphiphilic Oligomer Achieved by Hierarchical Construction of Self-Assembled Nanopores"
(2012) J. Am. Chem. Soc., 134, 19788-19794
published online

S. Enoki, R. Iino, N. Morone, K. Kaihatsu, S. Sakakihara, N. Kato and H. Noji
"Label-free single-particle imaging of the influenza virus by objective-type total internal reflection dark-field microscopy"
(2012) PLoS ONE, 7, e49208
published online

N. Hatsugai, V.P. Koldenkova, H. Imamura, H. Noji and T. Nagai
"Changes in Cytosolic ATP Levels and Intracellular Morphology during Bacteria-Induced Hypersensitive Cell Death as Revealed by Real-Time Fluorescence Microscopy Imaging"
(2012) Plant Cell Physiol., 53, 1768-1775
published online

S.H. Kim, S. Iwai, S. Araki, S. Sakakihara, R. Iino and H. Noji
"Large-scale femtoliter droplet array for digital counting of single biomolecules."
(2012) Lab Chip, 12, 4986-4991
published online

M. Tanigawara, K.V. Tabata, Y. Ito, J. Ito, R. Watanabe, H. Ueno, M. Ikeguchi and H. Noji
"Role of the DELSEED Loop in Torque Transmission of F1-ATPase."
(2012) Biophys. J., 103, 970-978
published online

N.E. Tirtom, Y. Nishikawa, D. Okuno, M. Nakano, K. Yokoyama and H. Noji
"Single-molecule analysis of inhibitory pausing states of V1-ATPase."
(2012) J. Biol. Chem., 287, 28327-28335
published online

H. You, R. Iino, R. Watanabe and H. Noji
"Winding single-molecule double-stranded DNA on a nanometer-sized reel."
(2012) Nucleic Acids Res., 40, e151
published online

R. Iino, K. Hayama, H. Amezawa, S. Sakakihara, S.H. Kim, Y. Matsumono, K. Nishino, A. Yamaguchi and H. Noji
"A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array"
(2012) Lab Chip, 12, 3923-3929
published online

S. Hayashi, H. Ueno, A.R. Shaikh, M. Umemura, M. Kamiya, Y. Ito, M. Ikeguchi, Y. Komoriya, R. Iino and H. Noji
"Molecular mechanism of ATP hydrolysis in F1-ATPase revealed by molecular simulations and single molecule observations"
(2012) J. Am. Chem. Soc., 134, 8447-8454
published online

Y. Komoriya, T. Ariga, R. Iino and H. Noji
"Principle role of the arginine finger in rotary catalysis of F1-ATPase"
(2012) J. Biol. Chem., 287, 15134-15142
published online

K. Sasagawa, K. Ando, T. Kobayashi, T. Noda, T. Tokuda, S.H. Kim, R. Iino, H. Noji and J. Ohta
"Complementary Metal–Oxide–Semiconductor Image Sensor with Microchamber Array for Fluorescent Bead Counting"
(2012) Jpn. J. Appl. Phys., 51, 02BL01
published online  

2011

R. Watanabe, D. Okuno, S. Sakakihara, K. Shimabukuro, R. Iino, M. Yoshida and H. Noji
"Mechanical modulation of catalytic power on F1-ATPase"
(2011) Nat. Chem. Biol., 8, 86-92
published online  

J. Kishikawa, M. Fujikawa, H. Imamura, K. Yasuda, H. Noji, N. Ishii, S. Mitani and K. Yokoyama
"Expression of ATP sensor protein in Caenorhabditis elegans"
(2011) Microscopy Research and Technique 2011
published online

T. Uchihashi, R, Iino, T. Ando and H. Noji
"High-speed atomic force microscopy reveals rotary catalysis of rotorless F1-ATPase"
(2011) Science, 333, 755-758
published online  

S. Furuike, M. Nakano, K. Adachi, H. Noji, K. Kinosita Jr. and K. Yokoyama
"Resolving stepping rotation in Thermus thermophilus H+-ATPase/synthase with an essentially drag-free probe"
(2011) Nat. Commun., 2, 233
published online

M. Nakano, H. Imamura, T. Nagai and H. Noji
"Ca2+ regulation of mitochondrial ATP synthesis visualized at the single cell level"
(2011) ACS Chem. Biol., 6, 709-715
published online

Y. Matsumoto, K. Hayama, S. Sakakihara, K. Nishino, H. Noji, R. Iino and A. Yamaguchi
"Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels"
(2011) PLoS ONE, 6, e18547
published online

2010

S. Sakakihara, S. Araki, R. Iino and H. Noji
"A single-molecule enzymatic assay in a directly accessible femtoliter droplet array"
(2010) Lab Chip, 10, 3355-3362
published online

R. Watanabe, R. Iino and H. Noji
"Phosphate-release in F1-ATPase catalytic cycle follows ADP release"
(2010) Nat. Chem Biol., 6, 814-820
published online  

D. Okuno, R. Iino, and H. Noji
"Stiffness of γ subunit of F1-ATPase"
(2010) Eur. Biophys. J., 39, 1589-1596
published oneline

K. Hayashi, H. Ueno, R. Iino and H. Noji
"Fluctuation theorem applied to F1-ATPase"
(2010) Phys. Rev. Lett., 104, 218103
published online

H. Ueno, S. Nishikawa, R. Iino, K.V. Tabata, S. Sakakihara, T. Yanagida and H. Noji
"Simple Dark-Field Microscopy with Nanometer Spatial Precision and Microsecond Temporal Resolution"
(2010) Biophys. J., 98, 2014-2023
published online

T. Ide, Y. Takeuchi, H. Noji and K.V. Tabata
"Simultaneous Optical and Electrical Single Channel Recordings on a PEG Glass"
(2010) Langmuir, 26, 8540-8543
published online

I. Kotera, T. Iwasaki, H. Imamura, H. Noji and T. Nagai
"Reversible dimerization of Aequorea victoria fluorescent proteins increases the dynamic range of FRET-based indicators"
(2010) ACS Chem. Biol., 5, 215-222
published online

2009

S.W. Lee, H. Kinoshita, H. Noji, T. Fujii and T. Yamamoto
"Biomolecular Nano-Flow-Sensor to Measure Near-Surface Flow"
(2009) Nanoscale Res. Lett., 5, 296–301
published online

T. Nakayama, M. Namura, K.V. Tabata, H. Noji and R. Yokokawa
"Sequential processing from cell lysis to protein assay on a chip enabling the optimization of an F1-ATPase single molecule assay condition"
(2009) Lab Chip, 9, 3567-3573
published online

Y. Iko, K.V. Tabata, S. Sakakihara, T. Nakashima and H. Noji
"Acceleration of the ATP-binding rate of F1-ATPase by forcible forward rotation."
(2009) FEBS Lett., 583, 3187-3191
published online

K.V. Tabata, K. Sato, T. Ide, T. Nishizaka, A. Nakano and H. Noji
"Visualization of cargo concentration by COPII minimal machinery in a planar lipid membrane"
(2009) EMBO J., 28, 3279-3289
published online

H. Imamura, K.P. Huynh Nhat, H. Togawa, K. Saito, R. Iino, Y. Kato-Yamada, T. Nagai and H. Noji
"Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators."
(2009) Proc. Natl. Acad. Sci. USA, 106, 15651-15656
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S. Enoki, R. Watanabe, R. Iino and H. Noji
"Single-molecule study on the temperature-sensitive reaction of F1-ATPase with a hybrid F1 carrying a single β(E190D)"
(2009) J. Biol. Chem., 284, 23169-13176
published online

Y. Hirono-Hara, H. Noji and S. Takeuchi
"Single-biomolecule observation with micro one-way valves for rapid buffer exchange."
(2009) J. Appl. Phys., 105, 102016
published online

R. Iino, R. Hasegawa, K.V. Tabata and H. Noji
"Mechanism of inhibition by C-terminal α-helices of the ε subunit of Escherichia coli FoF1-ATP synthase."
(2009) J. Biol. Chem., 284, 17457-17464
published online

2008

D. Okuno, R. Fujisawa, R. Iino, Y. Hirono-Hara, H. Imamura and H. Noji
"Correlation between the conformational states of F1-ATPase as determined from its crystal structure and single-molecule rotation."
(2008) Proc. Natl. Acad. Sci. USA, 105, 20722-20727
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S. Matsumoto, S. Yamaguchi, S. Ueno, H. Komatsu, M. Ikeda, K. Ishizuka, Y. Iko, K.V. Tabata, H. Aoki, S. Ito, H. Noji and I. Hamachi
"Photo Gel-Sol/Sol-Gel Transition and Its Patterning of a Supramolecular Hydrogel as Stimuli-Responsive Biomaterials."
(2008) Chem. Eur. J., 14, 3977-398
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L. Lam, S. Sakakihara, K. Ishizuka, S. Takeuchi, H.F. Arata, H. Fujita and H. Noji
"Loop-mediated isothermal amplification of a single DNA molecule in polyacrylamide gel-based microchamber."
(2008) Biomed. Microdevices., 10, 539-546
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R. Watanabe, R. Iino, K. Shimabukuro, M. Yoshida and H. Noji
"Temperature-sensitive reaction intermediate of F1-ATPase."
(2008) EMBO rep., 9, 84-90
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S. Yamaguchi, S. Matsumoto, K. Ishizuka, Y. Iko, K.V. Tabata, H.F. Arata, H. Fujita, H. Noji and I. Hamachi
"Thermally Responsive Supramolecular Nanomeshes for On/Off Switching of the Rotary Motion of F1-ATPase at the Single-Molecule Level."
(2008) Chem. Eur. J., 14, 1891-1896
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B. Le Pioufle, H. Suzuki, K.V. Tabata, H. Noji and S. Takeuchi
"Lipid bilayer microarray for parallel recording of transmembrane ion currents."
(2008) Anal. Chem., 80, 328-832
published online

2007

L. Lam, S. Sakakihara, K. Ishizuka, S. Takeuchi and H. Noji
"An integrated system for enzymatic cleavage and electrostretching of freely-suspended single DNA molecules."
(2007) Lab Chip, 7, 1738-1745
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K. Adachi, K. Oiwa, T. Nishizaka, S. Furuike, H. Noji, H. Itoh, M. Yoshida, K. Kinosita Jr.
"Coupling of Rotation and Catalysis in F1-ATPase Revealed by Single-Molecule Imaging and Manipulation"
(2007) Cell, 130, 309-321
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T. Nishinaka, Y. Doi, M. Hashimoto,R. Hara, T. Shibata, Y. Harada, K. KinositaJr, H. Noji and E. Yashima
"Visualization of RecA filaments and DNA by fluorescence microscopy."
(2007) J. Biochem. (Tokyo), 141, 147-156
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2006

E. Muneyuki, T. Watanabe-Nakayama, T. Suzuki, M. Yoshida, T. Nishizaka and H. Noji
"Single Molecule Energetics of F1-ATPase motor."
(2006) Biophys. J., 92, 1806-1812
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H.F. Arata, P. Low, K. Ishizuka, C. Bergaud, B. Kim, H. Noji and H. Fujita
"Temperature distribution measurement on microfabricated thermodevice for single biomolecular observation using fluorescent dye."
(2006) Sens. Actuators B-Chem., 117, 339-345
published online

S.W. Lee, T. Yamamoto, H. Noji and T. Fujii
"Chemical delivery microsystem for single-molecule analysis using multilaminar continuous flow."
(2006) Enzyme and Microb. Technol., 39, 519-525
published online

H.F. Arata, H. Noji and H. Fujita
"Motion control of single F1-ATPase rotary biomolecular motor using microfabricated local heating devices."
(2006) Appl. Phys. Lett., 88, 083902
published online

H. Suzuki, K.V. Tabata, H. Noji and S. Takeuchi
"Highly Reproducible Method of Planar Lipid Bilayer Reconstitution in Polymethyl Methacrylate Microfluidic Chip."
(2006) Langmuir, 22, 1937-1942
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2005

A.R. Laine, D. Okuno, K.V. Tabata, Y. Okada, A. Tixier-Mita, H. Noji and H. Fujita
"Gold functionalized nano-needles for angular protein movement visualization."
(2005) Nanobiotechnology, 1, 227-236
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H.F. Arata, Y. Rondelez, H. Noji and H. Fujita
"Temperature alternation by an on-chip microheater to reveal enzymatic activity of beta-galactosidase at high temperatures."
(2005) Anal. Chem., 77, 4810-4814
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Y. Hirono-Hara, K. Ishizuka, K. Kinosita Jr., M. Yoshida and H. Noji
"Activation of pausing F1 motor by external force."
(2005) Proc. Natl. Acad. Sci. USA, 102, 4288-4293
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Y. Rondelez, G. Tresset, T. Nakashima, Y. Kato-Yamada, H. Fujita, S. Takeuchi and H. Noji
"Highly coupled ATP synthesis by F1-ATPase single molecules."
(2005) Nature, 433, 773-777
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Y. Rondelez, G. Tresset, K.V. Tabata, H. Arata, H. Fujita, S. Takeuchi and H. Noji
"Microfabricated arrays of femtoliter chambers allow single molecule enzymology"
(2005) Nat. Biotech., 3, 361-365
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H. Noji, Y. Rondelez, T. Nakashima, G. Tresset, K.V. Tabata, Y. Kato-Yamada, H. Fujita and S. Takeuchi
"Ultra-small chamber for single-molecule detection of biological reaction"
(2005) e-J. Surf. Sci. Nanotech, 3, 79-81
published online

T. Ide, Y. Takeuchi, T. Aoki, K.V. Tabata and H. Noji
"An artificial lipid bilayer formed on a PEG-coated glass for simultaneous electrical and optical measurement of single ion-channels."
(2005) e-J. Surf. Sci. Nanotech, 3, 70-73
published online

2004

H. Suzuki H., K.V. Tabata, Y. Kato-Yamada, H. Noji and S. Takeuchi
"Planar lipid bilayer reconstitution with a micro-fluidic system"
(2004) Lab chip, 4, 502-505
published online

K. Atsuta, H. Noji and S. Takeuchi
"Micro patterning of active proteins with perforated PDMS sheets (PDMS sieve)"
(2004) Lab Chip, 4, 333-336
published online

H. Itoh, A. Takahashi, K. Adachi, H. Noji, R. Yasuda, M. Yoshida and K. Kinosita Jr.
"Mechanically driven ATP synthesis by F1-ATPase."
(2004) Nature, 427, 465-468
published online

T. Nishizaka, K. Oiwa, H. Noji, S. Kimura, E. Muneyuki, M. Yoshida and K. KinositaJr.
"Chemomechanical coupling in F1-ATPase revealed by simultaneous observation of nucleotide kinetics and rotation."
(2004) Nat. Struct. Mol. Biol., 11, 142-148
published online

2003

S. Ono, K.Y. Hara, J. Hirao, T. Matsui, H. Noji, M. Yoshida and E. Muneyuki
"Origin of apparent negative cooperativity of F1-ATPase."
(2004) Biochim. Biophys. Acta., 1607, 35-44
published online

R. Yasuda, T. Masaike, K. Adachi, H. Noji and K. Kinosita Jr.
"The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer."
(2004) Proc. Natl. Acad. Sci. USA, 100, 9314-9318
published online

H. Imamura, M. Nakano, H. Noji, E. Muneyuki, S. Ohkuma, M. Yoshida and K. Yokoyama
"Evidence for rotation of V1-ATPase"
(2004) Proc. Natl. Acad. Sci. USA, 100, 2312-2315
published online

2002

T. Ariga, T. Masaike, H. Noji and M. Yoshida
"Stepping rotation of F1-ATPase with 1, 2, or 3 altered catalytic sites that bind ATP only slowly."
(2002) J. Biol. Chem., 277, 24870-24874
published online

T. Masaike, E. Muneyuki, H. Noji, K. Kinosita Jr. and M. Yoshida
"F1-ATPase changes its conformations upon phosphate release."
(2002) J. Biol. Chem., 277, 21643-21649
published online

2001

Y. Hirono-Hara, H. Noji, M. Nishiura, E. Muneyuki, K.Y. Hara, R.Yasuda, K. Kinosita Jr. and M. Yoshida
"Pause and rotation of F1-ATPase during catalysis."
(2002) Proc. Natl. Acad. Sci. USA, 98, 13649-13654
published online

D. Bald, H. Noji, M. Yoshida, Y. Hirono-Hara and T. Hisabori
"Redox regulation of the rotation of F1-ATP synthase."
(2002) J. Biol. Chem., 276, 39505-7
published online

R. Yasuda, H. Noji, M. Yoshida, K. Kinosita Jr. and H. Itoh
"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase."
(2002) Nature, 410, 898-904
published online -->

H. Noji, D. Bald, R. Yasuda, H. Itoh, M. Yoshida and K. Kinosita Jr.
"Purine but not pyrimidine nucleotides support rotation of F1-ATPase."
(2002) J. Biol. Chem., 276, 25480-25486
published online

2000

K. Adachi, R. Yasuda, H. Noji, H. Itoh, Y. Harada, M. Yoshida and K. Kinosita Jr.
"Stepping rotation of F1-ATPase visualized through angle-resolved single-fluorophore imaging."
(2000) Proc. Natl. Acad. Sci. USA, 97, 7243-7247
publised online

K.Y. Hara, H. Noji, D. Bald, R. Yasuda, K. Kinosita Jr. and M. Yoshida
"The role of the DELSEED motif of the β subunit in rotation of F1-ATPase."
(2000) J. Biol. Chem., 275, 14260-14263
published online

D. Bald and H. Noji, M.T. Stumpp, M. Yoshida and T. Hisabori
"ATPase activity of a highly stable 33 subcomplex of thermophilic F1 can be regulated by the introduced regulatory region of γ subunit of chloroplast F1."
(2000) J. Biol. Chem., 275, 12757-12762
published online

S.P. Tsunoda, R. Aggeler, H. Noji, K. Kinosita Jr., M. Yoshida and R.A. Capaldi
"Observations of rotation within the FoF1-ATP synthase: deciding between rotation of the Foc subunit ring and artifact."
(2000) FEBS Lett., 470, 244-248
published online -->

T. Masaike, N. Mitome, H. Noji, E. Muneyuki, R. Yasuda, K. Kinosita Jr. and M. Yoshida
"Rotation of F1-ATPase and the hinge residues of the β subunit."
(2000) J. Exp. Biol., 203, 1-8
< published online

1999

T. Amano, T. Matsui, E. Muneyuki, H. Noji, K. Hara, M. Yoshida and T. Hisabori
3β3γ complex of F1-ATPase from thermophilic Bacillus PS3 can maintain steady-state ATP hydrolysis activity depending on the number of non-catalytic sites."
(1999) Biochem J., 343, 135-8.
published online

H. Noji, K. Hasler, W. Junge, K. Kinosita Jr., M. Yoshida and S. Engelbrecht
"Rotation of Escherichia coli F1-ATPase."
(1999) Biochem. Biophys. Res. Commun., 260, 597-599
published online

S.P. Tsunoda, E. Muneyuki, T. Amano, M. Yoshida and H. Noji
"Cross-linking of two β subunits in the closed conformation in F1-ATPase."
(1999) J. Biol. Chem., 274, 5701-5706
published online

1998

Y. Kato-Yamada, H. Noji, R. Yasuda, K. Kinosita Jr. and M. Yoshida
"Direct observation of the rotation of ε subunit in F1-ATPase."
(1998) J. Biol. Chem., 273, 19375-19377
published online

R. Yasuda, H. Noji, K. Kinosita Jr. and M. Yoshida
"F1-ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps."
(1998) Cell, 93, 1117-1124
published online

1997

H. Noji, R. Yasuda, M. Yoshida and K. Kinosita Jr.
"Direct observation of the rotation of F1-ATPase."
(1997) Nature, 386, 299-302
published online

2017

H. Noji, H. Ueno and D.G.G. Duncan
"Catalytic robustness and torque generation of the F1-ATPase"
(2017) Biophys. Rev., 9, 103-118
published online

2016

Y, Zhang and H. Noji
"Digital bioassay: Theory, applications, and perspectives."
(2016) Anal. Chem., 89, 92-101
published online

2013

R. Watanabe and H. Noji
"Chemomechanical coupling mechanism of F1-ATPase: Catalysis and torque generation"
(2013) FEBS Lett., 587, 1030-1035
published online

R. Iino and H. Noji
"Intersubunit coordination and cooperativity in ring-shaped NTPases"
(2013) Curr. Opin. Struct. Biol., 23, 229-234
published online

R. Iino and H. Noji
"Operation mechanism of FoF1-ATP synthase revealed by its structure and dynamics"
(2013) IUBMB Life, 238-246
published online

2012

R. Iino and H. Noji
"Rotary catalysis of the stator ring of F1-ATPase."
(2012) BBA – Bioenergetics, 1817, 1732-1739
published online

R. Iino, K. Nishino, H. Noji, A. Yamaguchi and Y. Matsumoto
"A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors."
(2012) Front. Microbiol., 3, 40
published online

2011

D. Okuno, R. Iino and H. Noji
"F1-ATPase: Fundamental properties and structure.
(2011) In “Encyclopedia of Biophysics” edited by Roberts G.C. Springer (India)."

H. Noji, D. Okuno and T. Ikeda
"Mechanochemistry of F1 motor protein."
(2011) Chem. Sci., DOI: 10.1039/C1SC00276G
PDF

D. Okuno, R. Iino and H. Noji
"Rotation and Structure of FoF1-ATP synthase"
(2011) J. Biochem., 149, 655-664
PDF

2010

D. Okuno, M. Ikeguchi and H. Noji
"Measurement of the conformational state of F1-ATPase by single-molecule rotation"
(2010) Methods Enzymol., 475, 279-296

2009

R. Iino, L. Lam, K.V. Tabata, Y. Rondelez, and H. Noji
"Single-molecule assay of biological reaction in femtoliter chamber array"
(2009) Jpn. J. Appl. Phys., 48, 08JA04
PDF

2008

R. Iino and H. Noji
"Two rotary motors in ATP-synthase"
“Single Molecule Dynamics in Life Science” Capter 10. Edited by Yanagida T and Ishii Y.
(2008) WILEY-VCH (Germany).

L. Lam, R. Iino, K.V. Tabata and H. Noji
"Highly-sensitive Restriction Enzyme Assay and Analysis:"
(2008) Anal. Bioanal. Chem., 391, 2423-2432

2006

R. Iino and H. Noji
"F1-ATPase: a highly coupled reversible rotary motor."
(2006) Biochem. Soc. Trans., 34, 993-6

2005

R. Iino, Y. Rondelez, M. Yoshida and H. Noji
"Chemomechanical coupling in single-molecule F-type ATP synthase."
(2005) J. Bioenerg. Biomembr., 37, 451-453

2003

H. Noji
F1-motor of ATP synthase.
"Molucular Motors. M. Schilwa (ed.)."
(2004) Wiley-VCH, 141-151

K. Adachi, H. Noji and K. Kinosita Jr.
"Single-molecule imaging of rotation of F1-ATPase."
(2004) Methods Enzymol., 361, 211-227

2002

H. Noji
"Molecular mechanism of torque generation in F1-motor"
(2002) Tanpakushitsu Kakusan Koso, 47, 1174-1181

2001

H. Noji and M. Yoshida
"The rotary machine in the cell, ATP synthase."
(2002) J. Biol. Chem., 276, 1665-1668

2000

K. Kinosita Jr., R. Yasuda and H. Noji
"F1-ATPase: a highly efficient rotary ATP machine."
(2000) Essays Biochem., 35, 3-18

E. Muneyuki, H. Noji, T. Amano, T. Masaike and M. Yoshida
"F0F1-ATP synthase: general structural features of 'ATP-engine' and a problem on free energy transduction."
(2000) Biochim. Biophys. Acta., 1458, 467-841

K. Kinosita Jr., R. Yasuda, H. Noji and K. Adachi
"A rotary molecular motor that can work at near 100% efficiency."
(2000) Philos. Trans. R Soc. Lond. B Biol. Sci., 355, 473-89

T. Masaike, N. Mitome, H. Noji, E. Muneyuki, R. Yasuda, K. Kinosita Jr. and M. Yoshida
"Rotation of F1-ATPase and the hinge residues of the beta subunit."
(2000) J. Exp. Biol., 203, 1-8

1999

H. Noji and M. Yoshida
"F1-ATPase; the stepping rotary motor in ATP synthase"
(1999) Seikagaku, 71, 34-50

1998

H. Noji
"The rotary enzyme of the cell: the rotation of F1-ATPase."
(1998) Science, 282:1844-5

K. Kinosita Jr., R. Yasuda, H. Noji, S. Ishiwata and M. Yoshida
"F1-ATPase: a rotary motor made of a single molecule."
(1998) Cell, 93, 21-24

1997

R. Yasuda, H. Noji, K. Kinosita Jr., F. Motojima and M. Yoshida
"Rotation of the gamma subunit in F1-ATPase; evidence that ATP synthase is a rotary motor enzyme."
(1997) J. Bioenerg. Biomembr., 29, 207-209

M. Yoshida, H. Noji and E. Muneyuki
"World smallest motor, ATP synthase"
(1997) Tanpakushitsu Kakusan Koso., 42, 1396-406

1996

H. Noji, T. Amano and M. Yoshida
"Molecular switch of F0F1-ATP synthase, G-protein, and other ATP-driven enzymes."
(1996) J. Bioenerg. Biomembr., 28, 451-457

野地研究室 Single Molecule Biophysics Noji Laboratory