Concept of Noji lab

Do science and create new technologies

For over two decades, we have been studying the molecular mechanism of ATP synthase with single molecule technology [1, 2]. Through our research, we have been creating novel and innovative technologies such as femtoliter reactor array [3], that is currently utilized in digital bioassays such as ELISA [4], and ratiometric fluorescent ATP sensor proteins such as ATeam [5] and BQueen [6]. Development of these new technologies is motivated more by our own curiosity rather than the need of the society. These technologies are widely used now and have been further developed by other researchers or companies. 1. H. Noji et al., 1997, Nature 386, 299-302
2. H. Noji, H. Ueno, and D.G.G. Duncan, 2016 Biophys. Rev. 9, 103-118
3. Y. Rondelez, et al., 2005 Nat. Biotech. 3, 361-5
4. S.H. Kim, et al., 2012 Lab Chip 12, 4986-4991
5. H. Imamura, et al., 2009 Proc. Natl. Acad. Sci. USA 106, 15651-15656
6. H. Yaginuma, et al., 2014 Sci. Rep. 4, 6522

野地研究室 Single Molecule Biophysics Noji Laboratory